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In recent years, the immunomodifiers used in the veterinary clinical practice for correction of immunodeficiency states of animals occurring under the influence of various adverse factors attract an extensive interest of research scientists and practitioners. Immunomodifiers are used due to worsening environmental situation and the increasing body burden of adverse anthropogenic factors, the growth of immune-dependent abnormalities, as well as the inefficiency of traditional methods of treatment of diseases, increase of pathogens’ resistance to drugs. The number of immune modulating drugs introduced in medical and veterinary practice has been steadily growing. In this situation, one should give preference to drugs of natural origin among which the nucleic acids have the most effective action, and above all, the RNA sodium salt, sodium nucleinate obtained by hydrolysis of baker's yeast.

SODIUM NUCLEINATE has a broad range of biological activity, accelerates regeneration processes, stimulates autarcesis factors, increases migration and cooperation of T- and B-lymphocytes, phagocytal activity of neutrophiles. Sodium nucleinate stimulates factors of congenital and acquired immunity activating proliferation of T-and B-lymphocytes. The main pharmacological property of nucleic acids is stimulation of leukopoiesis, regeneration and reparation processes, functional activity of almost all cells of the immune system. Formulations of nucleic acid group stimulate the functional activity of neutrophiles and monocytes/macrophages, enhancing their ability to absorb and kill the absorbed bacteria, enhance anti-infectious resistance to pathogenic microorganisms, probably, due to the stimulation of phagocytosis, increase the functional activity of T-lymphocytes, proliferation of B-cells and antibodies synthesis. Preparations of this group have antioxidant properties, which is manifested in their ability to remove free radicals from the body.

The great advantage of sodium nucleinate over other drugs of similar purpose is the lack of species specificity, side effects and severe immunological activity when administered orally.
SODIUM NUCLEINATE is manufactured as 0.2 % aqueous solution of low molecular fragments of yeast RNA sodium salt, packaged in ampoules and vials of 1.0–500 ml.

SODIUM NUCLEINATE is used in the complex treatment of all types of agricultural animals, small pets and birds as immune stimulating agents for diseases involving the development of immunodeficiency, including agranulocytosis and leukopenia, as non-specific means for enhancing prevention and treatment of viral, bacterial, fungal and parasitic diseases as well as for enhancing the effect of immunization with the prior or simultaneous use of the vaccine. It’s determined that the drug increases the immunogenic activity of vaccines, promotes the formation of a post-vaccination and post-infection hyperimmunity in salmonellosis, colibacillosis, rotavirus and coronavirus infection of calves and in salmonellosis of piglets and infectious diseases with complex etiological structure. The use of sodium nucleinate is efficient in immunodeficiencies of young stock of different age periods. In this case, the drug had an evident preventing and therapeutic effects, morbidity rate decreased and livability of animals increased.

The drug is effective for the prevention and removal of the effects of stressful states of animals during transportation, in the preoperative and postoperative periods, as well as in the treatment of a variety of non-contagious diseases in combination with other drugs.

Course of treatment is from 3–5 days to 30 days according to the instructions for application.

SODIUM NUCLEINATE is administered to animals by subcutaneous or intramuscular injections, it is also administered to birds with feed or water, and birds are also treated with aerosol. This shows that the prevention effect of the drug is associated with increased nonspecific resistance of animals against pathogens, which is formed in 4 hours after administration of sodium nucleinate.

During and after use of the drug livestock products can be used without restriction.

The drug is registered by the Federal Service for Veterinary and Phytosanitary Supervision of Russia.
Registration number: PVR-1-4.6/01777 as of November 14, 2006.

For contact and more information:
Tel.: +7 (845-2) 34-04-67, 34-07-08, , Gumenyuk Anatoly Petrovich

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